Thermo Fisher Scientific PCDHGC3 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
YKWKQSRDLYR APVSSLYRTP GPSLHADAVR GGLMSPHLYH QVYLTTDSRR SDPLLKKPGA ASPLASRQNT LRSCDPVFYR QVLGAES

• Highest antigen sequence identity to orthologs: mouse 98%, rat 95%

Target Information

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.

The gamma gene cluster includes 22 genes divided into 3 subfamilies:

• Subfamily A: 12 genes
• Subfamily B: 7 genes and 2 pseudogenes
• Subfamily C: 3 genes

Each variable region exon encodes the extracellular region, which includes six cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region.

These neural cadherin-like cell adhesion proteins likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.