Thermo Fisher Scientific RARRES2 Monoclonal Antibody (3D8)
RARRES2 단백질을 인식하는 Mouse IgG2a 단일클론 항체. ELISA에 적합하며, 인체 시료에 반응. Affinity chromatography로 정제된 액상 형태로 제공되며, 보존제 무첨가 PBS(pH 7.4) 용액에 저장. -20°C에서 보관, 반복 동결·해동은 피해야 함.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D8 |
| Immunogen | RARRES2 (NP_002880.1, 17 a.a. ~ 163 a.a) full-length recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
VGVAELTEAQ RRGLQVALEE FHKHPPVQWA FQETSVESAV DTPFPAGIFV RLEFKLQQTS CRKRDWKKPE CKVRPNGRKR KCLACIKLGS EDKVLGRLVH CPIETQVLRE AEEHQETQCL RVQRAGEDPH SFYFPGQFAF SKALPRS
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
Tazarotene-induced gene (TIG) proteins, also known as retinoic acid receptor responder proteins (RAR-responsive proteins), can be membrane-bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, endothelial cells, pancreas, spleen, and intestine.
TIGs are activated by tazarotene and mediate growth-suppressive effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. It is inhibited in psoriatic lesions and activated by tazarotene in skin rafts and epidermis of psoriatic lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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