Thermo Fisher Scientific RARRES2 Monoclonal Antibody (4C4)
RARRES2 단클론 항체(4C4)는 인간 RARRES2 단백질을 인식하는 Mouse IgG2a 항체로 Western blot과 ELISA에 적합합니다. GST 태그가 결합된 재조합 단백질을 면역원으로 사용하며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- H00005919-M26
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C4 |
| Immunogen | RARRES2 (NP_002880.1, 17–163 a.a) full-length recombinant protein with GST tag (MW of GST tag = 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
VGVAELTEAQ RRGLQVALEE FHKHPPVQWA FQETSVESAV DTPFPAGIFV RLEFKLQQTS CRKRDWKKPE CKVRPNGRKR KCLACIKLGS EDKVLGRLVH CPIETQVLRE AEEHQETQCL RVQRAGEDPH SFYFPGQFAF SKALPRS
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
Tazarotene-induced gene (TIG) proteins, also called retinoic acid receptor responder proteins (RAR-responsive proteins), can be membrane-bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, endothelial cells, pancreas, spleen, and intestine.
TIGs are activated by tazarotene and mediate growth suppression effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. It is inhibited in psoriatic lesions and activated by tazarotene in skin rafts and psoriatic epidermis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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