Thermo Fisher Scientific RARRES2 Monoclonal Antibody (3B4)
RARRES2 단백질을 인식하는 Mouse monoclonal antibody (Clone 3B4). Western blot 및 ELISA에 적합하며, Human 시료에 반응. Affinity chromatography로 정제된 액상 항체로, PBS(pH 7.4)에 보존제 없이 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B4 |
| Immunogen | RARRES2 (NP_002880.1, 17 a.a. ~ 163 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
VGVAELTEAQ RRGLQVALEE FHKHPPVQWA FQETSVESAV DTPFPAGIFV RLEFKLQQTS CRKRDWKKPE CKVRPNGRKR KCLACIKLGS EDKVLGRLVH CPIETQVLRE AEEHQETQCL RVQRAGEDPH SFYFPGQFAF SKALPRS
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs).
Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, and endothelial cells as well as in pancreas, spleen, and intestine.
TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. It is inhibited in psoriatic lesions and activated by tazarotene in skin rafts and epidermis of psoriatic lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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