Thermo Fisher Scientific PMCA1 Polyclonal Antibody
PMCA1 단백질을 인식하는 Rabbit polyclonal antibody로 Western blot 및 IHC에 사용 가능. 인간, 생쥐, 랫트 반응성. 합성 펩타이드 항원으로 제작. 동결건조 형태이며 장기 보관 시 -20°C 권장. 연구용으로만 사용.
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 710–760 of human PMCA1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity of this antibody: PMCA1.
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including the SERCA ATPase and the sodium/potassium pump.
There are four different genes encoding PMCA ATPase, and studies have revealed 20 isoforms generated by alternate splicing.
mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, while products 2 and 3 are more tissue-specific.
Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, beta cells express only the 4b isoform, while alpha and gamma cells express both 4a and 4b isoforms.
Different splice variants show different affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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