Thermo Fisher Scientific PMCA1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity of this antibody: PMCA1.

Target Information

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including the SERCA ATPase and the sodium/potassium pump.
There are four different genes encoding PMCA ATPase, and studies have revealed 20 isoforms generated by alternate splicing.
mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, while products 2 and 3 are more tissue-specific.
Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, beta cells express only the 4b isoform, while alpha and gamma cells express both 4a and 4b isoforms.
Different splice variants show different affinities for calcium and calmodulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.