Thermo Fisher Scientific PAPP-A/Pappalysin-1 Monoclonal Antibody (PAPPA, 2715)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

Pregnancy-associated plasma protein-A (PAPP-A, also known as Insulin-like growth factor binding protein-4 protease or PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein (~500 kDa) first discovered in serum from pregnant women.
The heterotetramer consists of two PAPP-A subunits and two proMBP subunits.
Low maternal serum levels of PAPP-A in first trimester biochemical screening are used as a marker of Down’s syndrome (trisomy 21).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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