Thermo Fisher Scientific PAPP-A/Pappalysin-1 Monoclonal Antibody (PAPPA, 2715)
인간 PAPP-A 단백질을 인식하는 단일클론 항체로 IHC 및 Peptide Array에 사용 가능. Mouse IgG2b, kappa 아이소타입이며, 비결합형 형태로 제공. 4°C에서 보관하며 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAPPA, 2715 |
| Immunogen | Recombinant fragment (within aa 351–523) of human PAPP-A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Pregnancy-associated plasma protein-A (PAPP-A, also known as Insulin-like growth factor binding protein-4 protease or PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein (~500 kDa) discovered in serum from pregnant women. It consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester screening are used as a marker for Down’s syndrome (trisomy 21).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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