Thermo Fisher Scientific HYPE Polyclonal Antibody
HYPE 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ELISA, IP에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| ELISA | 1:50,000 |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids within region 400–450 on mouse Protein adenylyltransferase FICD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Proprietary buffer with 30% glycerol |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context.
The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place.
Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP.
In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at Thr-518, thereby inactivating it.
In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at Thr-518, leading to restoration of HSPA5/BiP activity.
Although it is able to AMPylate RhoA, Rac, and Cdc42 Rho GTPases in vitro, these do not constitute physiological substrates.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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