Thermo Fisher Scientific RHD Recombinant Mouse Monoclonal Antibody (28D12)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:20–1:500

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system. These tightly linked genes map to human chromosomal position 1p34.1–1p36.

The RHD gene, commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen. Rh incompatibility between maternal and fetal blood types can result in hemolytic disease of the newborn (HDN), which may cause fetal death. The RHCE gene exists in four allelic forms, each determining the expression of two antigens in Ce, ce, cE, or CE combinations. The RHCED antigens are integral membrane proteins containing 12 transmembrane helices that maintain erythrocyte membrane integrity. Presentation of Rh antigenic activity requires complex formation between RHCED antigens and RHAG (RH50).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.