Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (Syn 505)
인간 알파 시뉴클레인(alpha-Synuclein)을 인식하는 Syn 505 클론 단일클론 항체. Western blot, IHC, ELISA 등 다양한 분석에 사용 가능. 단백질 A로 정제된 액상 형태로 제공되며, 안정적인 PBS 완충액에 보존. 파킨슨병 및 알츠하이머 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
- Publications: View 4 publications
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
- Publications: View 5 publications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: –
- Publications: View 1 publication
ELISA
- Tested Dilution: Assay-dependent
- Publications: View publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Horse, Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Syn 505 |
| Immunogen | Recombinant full-length oxidized human alpha-Synuclein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533225 |
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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