Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (Syn 505)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent
• Publications: View 4 publications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent
• Publications: View 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: –
• Publications: View 1 publication

ELISA

• Tested Dilution: Assay-dependent
• Publications: View publications

Product Specifications

Target Information

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.