Thermo Fisher Scientific Phospho-NDRG1 (Thr346) Polyclonal Antibody
NDRG1 단백질의 Thr346 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 사람, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NDRG1 (Accession Q92597), corresponding to amino acid residues around phosphorylated Thr346. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817590 |
Product Specific Information
This antibody detects endogenous levels of NDRG1 only when phosphorylated at Thr346.
Target Information
NDRG1 is a 394-amino-acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth, and differentiation.
Defects in NDRG1 cause Charcot-Marie-Tooth disease type 4D (CMT4D), characterized by reduced nerve conduction velocities, segmental demyelination and remyelination, slowly progressive distal muscle atrophy, weakness, absent deep tendon reflexes, and hollow feet.
NDRG1 serves as a marker of differentiation and is expressed in placental membranes, prostate, kidney, small intestine, ovary, colon, and luminal border cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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