Thermo Fisher Scientific SHARP Polyclonal Antibody
SHARP 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인간 샘플에 반응하며, 4°C 보관 및 Wet ice 배송.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 3375 and 3425 of Human SMART/HDAC1 associated repressor protein (spen homolog, transcriptional regulator) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses.
In osteoblasts, supports transcription activation and synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Acts as an essential corepressor protein regulating key pathways such as the Notch pathway.
Functions as a negative regulator of the Notch pathway via interaction with RBPSUH, preventing the association between NOTCH1 and RBPSUH, thereby suppressing Notch signaling.
Blocks the differentiation of precursor B-cells into marginal zone B-cells.
Likely represses transcription via recruitment of large complexes containing histone deacetylase proteins, and may bind both to DNA and RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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