Thermo Fisher Scientific LC3A (Cleaved Gly120) Polyclonal Antibody
Cleaved LC3A (Gly120)에 특이적인 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. Human 및 Mouse 반응성, Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS buffer에 0.09% sodium azide 포함, 장기 저장 시 -20°C 권장.
- 카탈로그번호
- PA535196
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LC3A (Cleaved Gly120) Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:25 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 89–120 amino acids from human Cleaved LC3A or LC3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552506 |
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
Target Information
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells. It is responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose cytoplasmic constituents targeted for degradation. These autophagosomes fuse with lysosomes (or vacuoles), releasing single-membrane bound autophagic bodies that are degraded within the lysosome (or vacuole).
MAP1A and MAP1B are microtubule-associated proteins that mediate interactions between microtubules and components of the cytoskeleton. They are involved in the formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3A is one of these light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic LC3-I form. LC3-I is activated by APG7L/ATG7, transferred to ATG3, and conjugated to phospholipid to form the membrane-bound LC3-II form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-35196_LC3A_Cleaved_Q9H492-1_Rabbit.svg, PA5-35196_LC3A_Cleaved_Q9H492-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.