Thermo Fisher Scientific Phospho-JIP1 (Thr103) Polyclonal Antibody
JIP1 단백질의 Thr103 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 최적화. 인간, 생쥐, 랫드 반응성. 고순도 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAPK8IP1 (Accession Q9UQF2), corresponding to amino acid residues around phosphorylated Thr103 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2815969 |
Product Specific Information
Antibody detects endogenous levels of JIP1 only when phosphorylated at Thr103.
Target Information
The protein encoded by this gene is a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to regulate c-Jun amino-terminal kinase (MAPK8). This protein prevents MAPK8-mediated activation of transcription factors and reduces IL-1β and MEKK1-induced apoptosis in pancreatic beta cells. It also functions as a DNA-binding transactivator of the glucose transporter GLUT2. REST is reported to repress the expression of this gene in insulin-secreting beta cells. Mutations in this gene have been found in families with type 2 diabetes, suggesting it may be a susceptibility gene for the disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-103270_JIP1_Q9UQF2-1_Rabbit.svg, PA5-103270_JIP1_Q9UQF2-1_Rabbit_PDP.jpeg)
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