Thermo Fisher Scientific PGP9.5/UchL1 Recombinant Mouse Monoclonal Antibody (rUCHL1, 775)
Thermo Fisher Scientific의 rUCHL1 (775) 마우스 단클론 항체는 PGP9.5/UchL1 단백질을 검출하기 위한 고품질 재조합 항체입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, 광범위한 종 반응성을 갖습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 7345-MSM5-P0
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host/Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rUCHL1, 775 |
| Immunogen | Recombinant full-length human UCHL1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Formalin-fixed tissues require heating in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
- This antibody shows broad species reactivity.
Target Information
PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase.
It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12).
PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.
PGP9.5 is present in:
- Neurons and nerve fibers throughout the central and peripheral nervous system
- Neuroendocrine cells
- Renal tubules
- Spermatogonia and Leydig cells of the testis
- Ova and corpus luteum cells
Altered expression of PGP9.5 is associated with:
- Overexpression: non-small cell lung cancer
- Decreased expression: Huntington and Alzheimer diseases
It serves as a useful neuronal marker and is valuable for studies of neurodegenerative disorders such as Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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