Thermo Fisher Scientific Phospho-VANGL2 (Ser11, Ser14) Recombinant Rabbit Monoclonal Antibody (4D3W2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.

Target Information

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acid protein in vertebrates, similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through its C-terminal region with the N-terminal half of DVL1, DVL2, and DVL3, and is a potent tumor suppressor.
VANGL2 is predominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of the neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.