Thermo Fisher Scientific ZEB1 Polyclonal Antibody
ZEB1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 850 and 900 of Human zinc finger E-box binding homeobox 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. It modulates promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) via recruitment of SMARCA4/BRG1. It also represses BCL6 transcription in the presence of the corepressor CTBP1, positively regulates neuronal differentiation, and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can cause corneal dystrophy, posterior polymorphous corneal dystrophy, and Fuchs endothelial corneal dystrophy type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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