Thermo Fisher Scientific PCBP1 Polyclonal Antibody
PCBP1 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody. Western blot, IHC, ChIP 등 다양한 응용에 적합. 인간에 반응하며, 다른 종에서도 예측 반응. 고순도 액상 형태로 안정적인 항체 검출에 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific PCBP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.01–0.03 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ADLAKLNQVARQQSH) corresponding to internal amino acids of PCBP1 (aa 234–247) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986697 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
This intronless gene (PCBP1) is thought to have originated via retrotransposition of a fully processed PCBP-2 mRNA. PCBP1 and PCBP-2 have paralogues arising from gene duplication events.
The encoded protein is multifunctional and, along with PCBP-2 and hnRNPK, forms major cellular polydomains involved in RNA binding.
PCBP1 and PCBP-2 act as translational coactivators of poliovirus RNA via interaction with stem-loop IV of the IRES and promote RNA replication through binding to the 5′-terminal cloverleaf structure.
It also plays roles in translational control of 15-lipoxygenase mRNA, HPV type 16 L2 mRNA, and hepatitis A virus RNA, and contributes to alpha-globin mRNA stability through formation of a specific mRNP complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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