Thermo Fisher Scientific Caspase 3 (CASP3) Monoclonal Antibody (OTI3A12)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CASP3 gene encodes a cysteine-aspartic acid protease (caspase) family member involved in the execution phase of apoptosis.
Caspase-3 exists as an inactive proenzyme that undergoes proteolytic processing to form active subunits.
It cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10.
Caspase-3 is also implicated in the cleavage of amyloid-beta precursor protein, associated with neuronal death in Alzheimer’s disease.
Alternative splicing produces two transcript variants encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.