Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
인간 alpha-synuclein을 인식하는 염소 폴리클로날 항체로, WB 및 IHC(P) 검증 완료. 비결합형 액상 형태이며 0.5 mg/mL 농도. 파킨슨병 연구 등 신경퇴행성 질환 관련 연구에 적합. -20°C 보관, 동결/해동 반복 피할 것.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KDQLGKNEEGAPQE (aa 97–110) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933591 |
Product Specific Information
This antibody is expected to recognize reported isoform NACP140 (NP_000336.1) only.
Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Alpha-synuclein is a member of the synuclein family (including beta- and gamma-synuclein). These brain-abundant proteins regulate synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting roles in signaling pathways.
Mutations in the SNCA gene (encoding alpha-synuclein) are linked to Parkinson’s disease pathogenesis. Alpha-synuclein peptides are also major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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