Thermo Fisher Scientific SIK2 Polyclonal Antibody
SIK2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 면역세포화학(ICC/IF)에 적합. 인간, 생쥐, 랫트 시료 반응성. 항원 친화 크로마토그래피 정제, PBS 버퍼 및 0.02% 아지드 포함. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid synthetic peptide near the center of human SIK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551691 |
Product Specific Information
- Suggested positive control: SW480 cell lysate
- PA5-34339 can be used with blocking peptide PEP-1254
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and a salt-inducible kinase belonging to the AMP-activated protein kinase family. It negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator TORC.
SIK2 is part of a signaling cascade that controls expression and activity of insulin-induced genes such as PGC-1α and UCP-1 in brown adipocytes, with implications in obesity and insulin resistance.
Additionally, SIK2 functions as a key regulator of neuronal survival after ischemia, suppressing CREB-mediated gene expression following oxygen-glucose deprivation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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