Thermo Fisher Scientific CD180 (RP105) Monoclonal Antibody (MHR73-11), PE, eBioscience
인간 CD180(RP105)을 인식하는 MHR73-11 단클론 항체로, PE 형광표지되어 있습니다. Flow Cytometry에 최적화되어 있으며, B세포 활성화 및 신호전달 연구에 유용합니다. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- 12-1809-42
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD180 (RP105) Monoclonal Antibody (MHR73-11), PE, eBioscience
Thermo Fisher Scientific CD180 (RP105) Monoclonal Antibody (MHR73-11), PE, eBioscience™
Applications
- Flow Cytometry (Flow): Tested at 5 µL (0.5 µg)/test
View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MHR73-11 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11042294 |
Additional Formats
Product Specific Information
The MHR73-11 monoclonal antibody reacts with human CD180 (RP105), a 105 kDa type I transmembrane molecule belonging to the TLR family. RP105 associates with MD-1 and is expressed on B cells, monocytes/macrophages, and dendritic cells. It plays a role in B cell activation, costimulatory molecule expression (CD80), and protection from apoptosis. RP105 loss correlates with B cell activation and disease activity in SLE patients.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated for use at 5 µL (0.5 µg)/test on normal human peripheral blood cells
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein in the Toll-like receptor (TLR) family. It lacks the TIR domain and requires MD-1 for expression. CD180 regulates LPS recognition and signaling through interaction with the TLR4 complex, leading to B cell activation and upregulation of CD80/CD86. It consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. CD180 dysfunction is associated with Kawasaki Disease and rheumatic disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.