Thermo Fisher Scientific TREX2 Polyclonal Antibody
TREX2 단백질을 인식하는 Goat Polyclonal 항체로, Human 시료에 반응합니다. Western blot과 IHC(P)에서 검증되었으며, 고순도의 액상 형태로 제공됩니다. DNA 손상 후 checkpoint 신호전달 연구에 유용한 연구용 항체입니다.
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- PA5142308
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-HRSSLENPEHDES |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932959 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
TREX2 is one of two major human 3' to 5' exonucleases required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in that gene cause Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined.
X-ray crystallography studies of TREX2–single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double-stranded DNA and feeds the substrate DNA strand into the TREX2 active site.
At least two isoforms of TREX2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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