Thermo Fisher Scientific SETD2 Polyclonal Antibody
SETD2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Flow Cytometry 및 Peptide ELISA에 사용 가능. H3K36me3 형성 관련 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SETD2 Polyclonal Antibody
Applications
Flow Cytometry (Flow)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-ERDPDKQTQNKE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex. H3K36me3 also plays an essential role in maintaining a heterochromatic state by recruiting DNA methyltransferase DNMT3A. Enhanced in intron-containing genes, suggesting SETD2 recruitment is coupled to splicing and elongating RNA polymerase. Required during angiogenesis and may regulate adenovirus 12 E1A gene expression upon infection.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.