Thermo Fisher Scientific SETD2 Polyclonal Antibody

Applications

Flow Cytometry (Flow)

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex. H3K36me3 also plays an essential role in maintaining a heterochromatic state by recruiting DNA methyltransferase DNMT3A. Enhanced in intron-containing genes, suggesting SETD2 recruitment is coupled to splicing and elongating RNA polymerase. Required during angiogenesis and may regulate adenovirus 12 E1A gene expression upon infection.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.