Thermo Fisher Scientific Proinsulin Monoclonal Antibody (1G4)
인슐린 전구체(Proinsulin)를 인식하는 마우스 단클론 항체. IHC, IHC(F), ELISA 등 다양한 응용에 사용 가능. 인간 시료에서 검증됨. 액상 형태로 2 mg/mL 농도, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | Reference |
| ELISA | Assay-dependent | Reference |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G4 |
| Immunogen | Purified human proinsulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Wet ice |
| RRID | AB_558518 |
Product Specific Information
MA1-21667 detects Proinsulin in Human samples.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids.
Insulin is a 51-amino acid polypeptide produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide.
Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of β-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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