Thermo Fisher Scientific c-Kit Monoclonal Antibody (104D2), PE
Flow Cytometry용 c-Kit (CD117) 단클론 항체로, PE 형광표지되어 세포 표면 단백질 분석에 적합. 인간, 소, 비인간 영장류에 반응하며, IgG1 아이소타입. 4°C 암조건 보관, 동결 금지. 연구용으로만 사용 가능.
- 카탈로그번호
- MA110073
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific c-Kit Monoclonal Antibody (104D2), PE
Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 104D2 |
| Immunogen | MOLM-1 megakaryocytic cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154337 |
Additional Formats
Product Specific Information
This antibody detects the extracellular region of CD117 / c-Kit proto-oncogene.
Target Information
KIT (c-KIT) is a proto-oncogene encoding a type III transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT regulates the growth and activation of various hematopoietic and non-hematopoietic cells. Mutations in KIT are linked to gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.
Upon ligand (SCF) binding, c-Kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues such as Tyr703. This enables downstream signaling through pathways like Ras/ERK, PI3K, PLC-γ, and JAK/STAT. c-Kit is essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.