Thermo Fisher Scientific c-Kit Monoclonal Antibody (104D2), PE
Flow Cytometry용 c-Kit (CD117) 단클론 항체로, PE 형광표지되어 세포 표면 단백질 분석에 적합. 인간, 소, 비인간 영장류에 반응하며, IgG1 아이소타입. 4°C 암조건 보관, 동결 금지. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 104D2 |
| Immunogen | MOLM-1 megakaryocytic cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154337 |
Additional Formats
Product Specific Information
This antibody detects the extracellular region of CD117 / c-Kit proto-oncogene.
Target Information
KIT (c-KIT) is a proto-oncogene encoding a type III transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT regulates the growth and activation of various hematopoietic and non-hematopoietic cells. Mutations in KIT are linked to gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.
Upon ligand (SCF) binding, c-Kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues such as Tyr703. This enables downstream signaling through pathways like Ras/ERK, PI3K, PLC-γ, and JAK/STAT. c-Kit is essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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