Thermo Fisher Scientific WTAP Monoclonal Antibody (OTI12G6), TrueMAB
Human WTAP 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western Blot과 IHC(P)에서 검증됨. TrueMAB 포맷으로 고순도 정제되어 있으며, PBS/BSA/glycerol buffer에 보관. WT1 관련 mRNA 스플라이싱 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12G6 |
| Immunogen | Human recombinant protein fragment (aa 2–106 of human WTAP) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Wilms’ tumor (WT) is an embryonal malignancy of the kidney affecting approximately 1 in 10,000 infants, occurring in both sporadic and inherited forms.
The Wilms’ tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a motif common to Egr family Zn²⁺ finger transcriptional activators, and acts as a transcriptional repressor.
WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may regulate mRNA splicing.
WTAP localizes to nuclear speckles and controls the G2/M cell cycle transition by stabilizing cyclin A2 mRNA through binding to its 3′ UTR.
Additionally, WTAP inhibits WT1 target gene expression and impairs WT1 DNA binding ability.
Two isoforms of WTAP exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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