Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI6C6), TrueMAB
인간 ABCC5 단백질을 인식하는 Mouse Monoclonal 항체로 Western Blot에 적합합니다. TrueMAB 형식으로 생산되었으며, 고순도의 Affinity chromatography 정제 항체입니다. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C6 |
| Immunogen | Full length human recombinant protein of human ABCC5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MRP subfamily, which is involved in multi-drug resistance. It functions in the cellular export of cyclic nucleotides, contributing to phosphodiesterase degradation and elimination pathways.
Studies show resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.
Alternative splicing has been detected; however, the complete sequence and translation initiation site remain unclear.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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