Thermo Fisher Scientific PLK1 Polyclonal Antibody
PLK1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 세포 증식 및 암 연구에 활용 가능. Human 반응성, 액상 형태, 항원 친화 크로마토그래피로 정제. 권장 희석 배율 ICC/IF 1:100–1:500, 4°C 보관.
- 카탈로그번호
- IHC00071x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PLK1 Polyclonal Antibody
Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 325 and 375 of Human Polo-like kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, antibody predicted to react with Rabbit, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and White-tufted-ear marmoset
Target Information
PLK1 (Polo-like kinase 1) is a serine/threonine kinase involved in cell mitosis and serves as a marker of cell proliferation. It plays a critical role in carcinogenesis by binding and phosphorylating proteins that are already phosphorylated on specific motifs recognized by POLO box domains.
PLK1 phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, and WEE1.
It plays a key role in centrosome function and bipolar spindle assembly through phosphorylation of KIZ, NEDD1, and NINL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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