Thermo Fisher Scientific IL-23 p19 Monoclonal Antibody (727753), PE

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Product Specific Information

In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) IL-23 heterodimer is observed, less than 10% cross-reactivity with recombinant mouse (rm) IL-23 heterodimer is observed, and no cross-reactivity with recombinant feline IL-23 p19, recombinant canine (rca) IL-23 p19, and recombinant rat IL-23 p19 is observed.
In Western blots, no cross-reactivity with rcaIL-23 p19 or rmIL-23 p19 is observed.

Target Information

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. The p19 subunit, similar to p35 of IL-12, is biologically inactive alone.
IL-23 interacts with IL-12Rβ1 and an additional β2-like receptor subunit with STAT4 binding domain, termed IL-23R.
It is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 differ from mouse IL-12; IL-23 induces strong proliferation of memory T cells and activation to produce IL-17, while IL-12 does not.
Human IL-23 induces proliferation of memory T cells and moderate IFN-γ production compared to IL-12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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