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Thermo Fisher Scientific BMI1 Monoclonal Antibody (BMI1, 2690)
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BMI1 단백질을 인식하는 mouse monoclonal 항체로, 인간 시료에 반응합니다. IHC(P) 및 Peptide Array에 사용 가능하며, Protein A/G로 정제된 200 µg/mL 액상 형태입니다. 4°C 보관, 연구용으로만 사용됩니다.
- 카탈로그번호
- 648-MSM2-P1
- 판매단위
- pk
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마지막 업데이트 2025. 08. 05. 오전 01:35
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Thermo Fisher Scientific 648-MSM2-P1 BMI1 Monoclonal Antibody (BMI1, 2690) 100 ug pk판매 단위 pk ·
재고 확인 필요
825,100원VAT 포함 907,610원
Thermo Fisher Scientific · Thermo Fisher Scientific BMI1 Monoclonal Antibody (BMI1, 2690)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BMI1, 2690 |
| Immunogen | Recombinant fragment (around aa 142–326) of human BMI1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
BMI1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development.
The PcG PRC1 complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A (Lys-119), thereby altering chromatin expressibility.
Within the PRC1 complex, BMI1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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