Thermo Fisher Scientific BMI1 Monoclonal Antibody (BMI1, 2690)
BMI1 단백질을 인식하는 mouse monoclonal antibody로, IHC(P) 및 peptide array에 사용 가능. Human 시료 반응성. Protein A/G로 정제된 액상 항체이며 보존제 무첨가. -20°C 이하에서 보관 권장. 연구용으로만 사용.
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- 648-MSM2-P1ABX
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BMI1, 2690 |
| Immunogen | Recombinant fragment (around aa 142–326) of human BMI1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
BMI1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development.
The PcG PRC1 complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, resulting in heritable changes in chromatin expressibility.
Within the PRC1 complex, BMI1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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