Thermo Fisher Scientific DKK3 Polyclonal Antibody
DKK3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. Recombinant DKK3 단백질을 면역원으로 제작되었으며, 높은 특이성과 예측된 다종 반응성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 6–343 (Q9UBP4) of DKK3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.56 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152165 |
Product Specific Information
- Recommended positive controls: A549, mouse brain
- Predicted reactivity: Mouse (85%), Rat (81%), Dog (87%), Pig (88%), Rhesus Monkey (97%), Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and two conserved cysteine-rich domains separated by a linker region containing 10 cysteine residues each. The second cysteine region may have a lipid-binding function facilitating WNT/DKK interactions at the plasma membrane. The linker region contains 50–55 amino acids in DKK1, DKK2, and DKK4, but only 12 amino acids in DKK3. All DKKs have potential cleavage sites for furin-type proteases.
Northern blot analysis shows wide expression of the DKK3 transcript, with highest levels in heart, brain, and spinal cord. In situ hybridization reveals high expression in mouse brain, eye, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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