Thermo Fisher Scientific IL17RA Monoclonal Antibody (133617)
IL17RA 단일클론 항체로 인간 IL-17RA를 특이적으로 인식하며, Western blot, Flow cytometry, Neutralization 등에 사용 가능. 단백질 A/G로 정제된 무보존제 제형으로 안정적이며, 염증 및 자가면역 연구에 적합.
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Thermo Fisher Scientific IL17RA Monoclonal Antibody (Clone 133617)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 0.25 µg per million cells |
| Neutralization (Neu) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 133617 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-17RA/IL-17R (Leu33–Trp320) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606115 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant mouse IL‑17R, IL‑17BR, or recombinant human IL‑17BR is observed.
- In Western blots, no cross-reactivity with recombinant mouse IL‑17R is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg antibody (LAL method).
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It induces maturation of CD34-positive hematopoietic precursors into neutrophils.
IL-17RA is a type I membrane glycoprotein binding IL-17A and IL-17F with low affinity. IL-17A and its receptor are implicated in inflammatory and autoimmune diseases such as rheumatoid arthritis.
Defects in IL-17RA cause familial candidiasis type 5 (CANDF5), characterized by altered immune responses and impaired fungal clearance.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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