Thermo Fisher Scientific CD38 Chimeric Recombinant Rabbit Monoclonal Antibody (AT13/5)

Applications

Product Specifications

Product Specific Information

Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein expressed on pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, NK lymphocytes, myeloblasts, and erythroblasts. CD38 expression is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7, which binds to an epitope between amino acids 273–285.

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD+ glycohydrolase) and as a cell surface receptor.
Antibodies to CD38 are useful for subtyping lymphomas and leukemias, detecting plasma cells (e.g., myelomas), and identifying activated B and T cells. CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is expressed at high levels in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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