Thermo Fisher Scientific CD38 Chimeric Recombinant Rabbit Monoclonal Antibody (AT13/5)
Human CD38 단백질을 특이적으로 인식하는 재조합 토끼 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. HEK293 발현 시스템 기반, Protein A로 정제된 액상 형태. 면역세포 표지 및 림프구 활성 연구에 적합.
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Applications
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AT13/5 |
| Immunogen | Namalwa cells emulsified in CFA. Target Family: CD38, UniProt ID: P28907-1, NCBI Node ID: 9606, Antigen Range: 1–300, Antigen Length: 300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074320 |
Product Specific Information
Binds specifically to human CD38, an approximately 45 kDa type II transmembrane protein expressed on pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, NK lymphocytes, myeloblasts, and erythroblasts. CD38 expression is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone HB7, which binds to an epitope between amino acids 273–285.
Target Information
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD+ glycohydrolase) and as a cell surface receptor.
Antibodies to CD38 are useful for subtyping lymphomas and leukemias, detecting plasma cells (e.g., myelomas), and identifying activated B and T cells. CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is expressed at high levels in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-47876_CD38_P28907-1_Rabbit.svg, MA5-47876_CD38_P28907-1_Rabbit_PDP.jpeg)
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