Thermo Fisher Scientific PATZ1 Monoclonal Antibody (OTI2D2), TrueMAB
PATZ1 단백질을 인식하는 Mouse monoclonal 항체로, Western blot에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D2 |
| Immunogen | Full length human recombinant protein of human PATZ1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene contains an A-T hook DNA binding motif that interacts with other DNA-binding structures, playing an important role in chromatin modeling and transcription regulation. The POZ domain mediates protein-protein interactions required for transcriptional repression, while zinc-finger domains enable DNA binding. This protein likely functions as a transcriptional repressor. In small round cell sarcoma, the gene is fused with EWS by an inversion of chromosome 22q, forming a hybrid translocation t(1;22)(p36.1;q12). This rearrangement fuses the EWS transactivation domain with the zinc finger domain of this protein, representing an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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