Thermo Fisher Scientific USP13 Polyclonal Antibody
USP13 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 BSA와 글리세롤이 포함되어 있으며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- PA531222
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 597–817 of Human USP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2548696 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, mouse brain, K562
- Predicted reactivity: Mouse (92%), Rat (88%), Rhesus Monkey (99%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilization of the PIK3C3/VPS34-containing complexes.
Also deubiquitinates USP10, an essential regulator of p53/TP53 stability.
Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating ERAD.
Mediates stabilization of SIAH2 independently of deubiquitinase activity by impairing SIAH2 autoubiquitination.
Has a weak deubiquitinase activity in vitro and preferentially cleaves Lys-63-linked polyubiquitin chains.
Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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