Thermo Fisher Scientific S1P1 Polyclonal Antibody
S1P1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 이동 및 신호전달 연구용으로 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the carboxy terminus of the human S1P1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155829 |
Product Specific Information
- A suggested positive control is mouse thymus tissue lysate.
- PA5-20610 can be used with blocking peptide PEP-0730.
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins.
S1P1 signaling leads to activation of RAC1, SRC, PTK2/FAK1, and MAP kinases.
It plays an important role in cell migration via reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase SPHK1 activity.
S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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