Thermo Fisher Scientific ELL2 Polyclonal Antibody
ELL2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 4°C에서 보관하며, 연구용으로만 사용 가능.
- 카탈로그번호
- A302505A
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 450 of human elongation factor, RNA polymerase II, 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It contains two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, SHP-1 binds to tyrosine-phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and downregulation of Ros-dependent proliferation and transformation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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