Thermo Fisher Scientific GLDC Polyclonal Antibody
GLDC 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 GLDC에 반응합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GLDC. Recombinant protein control fragment (Product #RP-103139). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642029 |
Product Specific Information
Immunogen sequence:
SCTMKLNSSS ELAPITWKEF ANIHPFVPLD QAQGYQQLFR ELEKDLCELT GYDQVCFQPN SGAQGEYAGL ATIRAYLNQK GEGHRTVCLI PKSAHGTNPA SAHMAGMKIQ PVEVDKYGNI DAVHLKAMVD KHKENL
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 92%
Target Information
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components:
- P protein (pyridoxal phosphate-dependent glycine decarboxylase)
- H protein (lipoic acid-containing protein)
- T protein (tetrahydrofolate-requiring enzyme)
- L protein (lipoamide dehydrogenase)
The P protein binds to glycine and transfers the methylamine group from glycine to the T protein.
Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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