Thermo Fisher Scientific E2AK2/PKR Polyclonal Antibody
PKR 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 바이러스 감염 및 신경퇴행성 질환 연구에 적합.
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Thermo Fisher Scientific E2AK2/PKR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PKR (amino acids 251–360) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. PKR plays a key role in antiviral defense through activation by double-stranded RNA produced during viral infection. It is involved in IFN-induced antiviral response, virus-induced apoptosis, and regulation of cell growth and differentiation.
PKR induces apoptosis by up-regulating Fas expression and mediates the FADD/Caspase-8 death signaling pathway. Upon viral infection, PKR functions as a dual protein, activating both cell survival and death pathways through kinase-dependent and independent mechanisms. It regulates multiple pathways including NF-kappaB activation, p53, p38, and PDGF signaling. PKR has been implicated in tumor suppression and malignancy, as well as in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis. Viruses have evolved mechanisms to evade PKR, such as inhibition by influenza virus NS1 protein.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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