Thermo Fisher Scientific Apollon/BIRC6 Polyclonal Antibody
Apollon/BIRC6 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며, Protein A로 정제된 1 mg/mL 액상 제품. 세포사멸 관련 연구용으로 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Apollon, amino acids 4701–4857 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis, or programmed cell death, is related to many diseases such as cancer. Apoptosis is triggered by various stimuli including TNF family members and can be inhibited by IAP (Inhibitor of Apoptosis) proteins.
BRUCE, also known as BIRC6, is an IAP family protein containing a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain.
BRUCE regulates p53 and the mitochondrial pathway of apoptosis by promoting ubiquitination and degradation of apoptotic proteins such as Caspase-9 and SMAC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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