Thermo Fisher Scientific Thioredoxin 2 Recombinant Rabbit Monoclonal Antibody (ARC1003)
Thioredoxin 2 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, ELISA 등에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 액상 형태로 제공되며 -20°C에서 안정적으로 보관 가능.
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Thermo Fisher Scientific Thioredoxin 2 Recombinant Rabbit Monoclonal Antibody (ARC1003)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1003 |
| Immunogen | Synthetic peptide corresponding to amino acids 67–166 of human TXN2 (UniProt Q99757) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3), 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849414 |
Product Specific Information
Immunogen sequence:
GPDFQDRVVN SETPVVVDFH AQWCGPCKIL GPRLEKMVAK QHGKVVMAKV DIDDHTDLAI EYEVSAVPTV LAMKNGDVVD KFVGIKDEDQ LEAFLKKLIG
Target Information
Thioredoxins (Trx) are small, multifunctional proteins with oxidoreductase activity and are ubiquitous in living cells. They contain a conserved Cys-Gly-Pro-Cys active site forming redox-active disulfide/dithiol groups. The active site disulfide can be reduced by thioredoxin reductase using NADPH as an electron donor. Reduced Trx serves as a hydrogen donor for ribonucleotide reductase, essential for DNA synthesis, and functions as a general protein disulfide reductase involved in growth and redox regulation. Trx reduces targets such as protein disulfide-isomerase (PDI) and transcription factors including p53, NF-κB, and AP-1. It also contributes to H₂O₂ removal when coupled with methionine sulfoxide reductase or peroxiredoxin isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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