Thermo Fisher Scientific LC3B Polyclonal Antibody
LC3B 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF, ELISA에 적합. 인간, 생쥐, 랫드 반응성. 자가포식 연구 및 세포 내 단백질 분석에 활용 가능. 고순도 Affinity chromatography로 정제된 액상 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human LC3B (NP_073729.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.14 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901721 |
Product Specific Information
- Positive samples: C6, HeLa, NIH/3T3, Pig liver
- Immunogen sequence:
MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE
Target Information
LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3B) is encoded by the MAP1LC3B gene in humans.
LC3B is involved in microtubule assembly and neurogenesis, and plays a vital role in autophagy, the process of bulk degradation of cytoplasmic components.
Three human LC3 isoforms undergo post-translational modifications during autophagy.
Macroautophagy is the major inducible pathway for turnover of cytoplasmic constituents, responsible for degradation of cytoplasmic enzymes and organelles during nutrient starvation.
LC3B mediates interactions between microtubules and cytoskeletal components, and may be involved in cancer, aging, metabolic, neurodegenerative, and cardiovascular/pulmonary disorders.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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