Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (Syn 211)
인간 알파시뉴클레인(alpha-synuclein)에 특이적인 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 베타 및 감마 시뉴클레인과 교차 반응하지 않으며, 파킨슨병 및 신경퇴행성 질환 연구에 활용됩니다. 액상 형태로 제공되며 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | 21 publications |
| Immunohistochemistry (IHC) | Assay-dependent | 13 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 2 publications |
| Immunohistochemistry – Free Floating (IHC (Free)) | – | 1 publication |
| Immunocytochemistry (ICC/IF) | – | 9 publications |
| ELISA | Assay-dependent | – |
| Immunoprecipitation (IP) | – | 2 publications |
| Dot blot (DB) | – | 3 publications |
| Miscellaneous PubMed (Misc) | – | 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Bacteria, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Syn 211 |
| Immunogen | Recombinant human alpha-synuclein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533094 |
Product Specific Information
This antibody reacts specifically with alpha-synuclein protein and does not cross-react with beta- or gamma-synuclein or synoretin. Reactivity was confirmed with human samples. Reactivity with other species has not been tested.
Target Information
Alpha-synuclein belongs to the synuclein protein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting a role in signaling pathways. Mutations in the SNCA gene, encoding alpha-synuclein, are associated with Parkinson’s disease. Alpha-synuclein peptides are also major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified. Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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