Thermo Fisher Scientific CKMT1A Polyclonal Antibody
Thermo Fisher Scientific CKMT1A Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 CKMT1A 단백질 검출용으로 최적화된 rabbit IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 저장 조건을 제공합니다.
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Thermo Fisher Scientific CKMT1A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CKMT1A; CKMT1B (Accession P12532), corresponding to amino acid residues F30–T80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854023 |
Product Specific Information
Antibody detects endogenous levels of total CKMT1A.
Target Information
Mitochondrial creatine kinase (MtCK) is responsible for transferring high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. MtCK occurs in two oligomeric forms—dimers and octamers—unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. Overexpression of ubiquitous MtCK has been observed in malignant cancers with poor prognosis, possibly linked to high energy turnover and impaired apoptosis. Ubiquitous MtCK shares 80% homology with sarcomeric MtCK coding exons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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