Thermo Fisher Scientific CPSF4 Polyclonal Antibody
CPSF4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제. PBS/glycerol 완충액에 보관되며 -20°C에서 안정적.
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CPSF4 (Accession O95639), corresponding to amino acid residues L206–N256 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854025 |
Product Specific Information
Antibody detects endogenous levels of total CPSF4.
Target Information
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4 (CPSF4), an essential component of the 3′ end processing machinery of cellular pre-mRNAs.
In influenza virus-infected cells, NS1 protein binds to CPSF4 and inhibits CPSF binding to RNA substrates, thereby blocking 3′ end cleavage and polyadenylation of host pre-mRNAs. This results in selective inhibition of host mRNA nuclear export, while viral mRNA export remains unaffected.
Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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