Thermo Fisher Scientific C1orf55 Polyclonal Antibody
C1orf55 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC 및 IHC(Paraffin) 실험에 적합합니다. 인간 반응성, 항원 친화 크로마토그래피 정제, 4°C 보관, 연구용으로만 사용됩니다.
- 카탈로그번호
- IHC00526x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific C1orf55 Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 350 and 400 of human chromosome 1 open reading frame 55 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Crab-eating macaque
Target Information
C1orf55 (also known as SDE2) is involved in both DNA replication and cell cycle control (PubMed:27906959).
Unprocessed SDE2 interacts with PCNA via its PIP-box, preventing PCNA monoubiquitination and inhibiting translesion DNA synthesis.
Binding of SDE2 to PCNA leads to processing by a deubiquitinating enzyme, removing the N-terminal ubiquitin-like domain.
The mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage-dependent manner.
Binding of SDE2 to PCNA is essential to counteract UV-induced replication stress, and complete degradation of SDE2 allows S-phase progression.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: IHC-00526_SDE2_Q6IQ49-1_Rabbit.svg, IHC-00526_SDE2_Q6IQ49-1_Rabbit_PDP.jpeg)
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