Thermo Fisher Scientific UNC93B1 Polyclonal Antibody
UNC93B1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 사용 가능. 고순도 항원 친화 크로마토그래피로 정제됨. 4°C 또는 -20°C에서 안정적 저장 가능. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested dilution: Not specified
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UNC93B1. Recombinant protein control fragment (Product #RP-104695) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790592 |
Product Specific Information
Immunogen sequence:
NYITRMAQKY HEYSHYKEQD GQGMKQRPPR GSHAPY
Target Information
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was identified by a forward genetic screen using N-ethyl-N-nitrosourea. A histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7, and 9 signaling.
Unlike Unc93a, whose function is unknown, Unc93b specifically interacts with TLR3, 7, and 9. The mutation abolishes this interaction, and mice carrying this mutation are highly susceptible to viral infections, indicating Unc93b’s essential role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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