Thermo Fisher Scientific p23 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
CVEDSKDVNV NFEKSKLTFS CLGGSDNFKH LNEIDLFHCI DPNDSKHKRT DRSILCCLRK GESGQSWPRL T

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion.

Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (FKBP52, FKBP54, and CyP-40), and other proteins termed p23, p60, and p48. p23, along with HSP70, HSP90, and p60, combines with progesterone receptor (PR) as members of a transient intermediate complex.

Cloned human p23 encodes a protein of 160 amino acids, highly conserved between species, and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies suggest that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While its exact function and mechanism remain unclear, p23 appears to be an important factor in PR function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.