Thermo Fisher Scientific p23 Polyclonal Antibody
p23 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등에 사용 가능. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로 안정적인 보관 및 재현성 높은 결과 제공.
- 카탈로그번호
- PA583435
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTGES3. Recombinant protein control fragment (Product #RP-97668). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790590 |
Product Specific Information
Immunogen sequence:
CVEDSKDVNV NFEKSKLTFS CLGGSDNFKH LNEIDLFHCI DPNDSKHKRT DRSILCCLRK GESGQSWPRL T
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion.
Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (FKBP52, FKBP54, and CyP-40), and other proteins termed p23, p60, and p48. p23, along with HSP70, HSP90, and p60, combines with progesterone receptor (PR) as members of a transient intermediate complex.
Cloned human p23 encodes a protein of 160 amino acids, highly conserved between species, and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies suggest that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While its exact function and mechanism remain unclear, p23 appears to be an important factor in PR function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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